Teriparatide

  • Description
Product Detail

Chemical Name:Teriparatide

CAS# 52232-67-4

Sequence: Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH

Molecular Formula: C181H291N55O51S2

Molecular Weight: 4117.72

Indication: 

it is effective in women with postmenopausal osteoporosis, men with idiopathic or hypogonadal osteoporosis and patients with glucocorticoid-induced osteoporosis. Teriparatide improves bone mineral density (BMD) and alters the levels of bone formation and resorption markers; histomorphometric studies showed teriparatide-induced effects on bone structure, strength and quality. 

TEST ITEMS

SPECIFICATIONS

RESULTS

Appearance

White powder

Conforms

Solubility

Soluble in water or 1% acetic acid
at a concentration of =1mg/ml to
give a clear, colorless solution

Conforms

Specific Optical Rotation(c=0.5,1% HAc)- -65.0~-75.0°-70.2°

Identity

Monoisotopic Mass: 4117.7±2.0

4116.0

Amino Acid Composition

±20%

Conforms

Related Substances

 

Total Impurities(%)= 5.0%

Largest Single Impurity(%)= 2.0%

0.8%
0.3%

Peptide Purity (By HPLC)

= 95.0% by area integration

99.3%

Acetate Content

= 15%

9.0%

Water Content(Karl Fischer)

= 8.0%

2.5%

Peptide Content(N determination)= 80.0%88.3%

Assay(By Anhydrous, Acetic Acid-free )

95.0~105.0%



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